Saturday, January 26, 2008

The Cure Is Near!

Here is good news to all sufferers of Type 1 diabetes, like my daughter.

New Stem Cell Discovery May Treat Diabetes

Researchers in Belgium have significantly advanced the discovery of a pancreatic progenitor cell with the capacity to generate new insulin-producing beta cells. If the finding made in mice holds for humans, the newfound progenitor cells may represent “an obvious target for therapeutic regeneration of beta cells in diabetes,” the researchers report in the Jan. 25 issue of the research journal Cell, a publication of Cell Press. In people with type 1 diabetes, blood sugar rises due to a loss of the insulin-producing pancreatic beta cells. Insulin is a hormone that helps the body use glucose for energy.
“One of the most interesting characteristics of these [adult] progenitor cells is that they are almost indistinguishable from embryonic progenitor cells,” said Harry Heimberg at the Juvenile Diabetes Research Foundation Center at Vrije Universiteit Brussel in Belgium and the Beta Cell Biology Consortium. “In terms of their structure and gene expression, there are no major differences. They look and behave just like embryonic beta cell progenitors."

“We at JDRF believe that this new research provides novel insights that may provide therapeutic potential to regenerate beta cells in type 1 diabetes,” said Patricia Kilian, Regeneration Program Director at JDRF.
Previous studies have suggested the existence of a beta cell progenitor in the pancreas after birth, but the identification and characterization of the progenitor cell has not been fully achieved. Other studies showing that replication of adult beta cells can account for beta cell turnover and expansion of beta cells under normal physiologic conditions and called into question the role or existence of a progenitor cell in regeneration. “Most people gave up looking because the cells are so few and so hard to activate,” added Heimberg.
In the new study, Heimberg’s team tied off a duct that drains digestive enzymes from the pancreas, a manipulation that led to a doubling of beta cell mass in the injured part of the pancreas within two weeks. The animals’ pancreases also began producing more insulin, evidence that the new beta cells were fully functional.
Using a genetic labeling technique, the researchers found that the new beta cells were derived from precursor cells that expressed a gene expressed in embryonic progenitor cells called Neurogenin 3 (Ngn3) and that production of the new beta cells depended on activity of this gene. He suspects the regenerative process is sparked by an inflammatory response in the enzyme-flooded pancreas.
“The most important challenge now is to extrapolate our findings to patients with diabetes,” Heimberg reported. Although he cautioned that any potential diabetes treatment remains in the future, he said “our findings reveal the significance of investigating the feasibility of both isolating facultative beta cell progenitors and newly formed beta cells from human pancreas in order to expand and differentiate them in vitro and transplant them in diabetic patients and also composing a mix of factors able to activate beta cell progenitors to expand and differentiate in situ in patients with an absolute or relative deficiency in insulin.”
On the Net:

At this time I'd like to send out tribulations to all that have given so graciously to J.D.R.F.
Without your support, hard work, and donations, none of this could ever have happened.
We're not there yet, but we're oh so close.
Don't give up the ship, keep going the rewards are at our grasp!

Fuck You George Bush and Stephen Harper! Thanx fer noth'n! Ya phony religious nut jobs!
Go suck big oil's dick!!!

8 Don't Just Sit There Say Sumthin !:

handmaiden said...

It's encouraging that medical science keeps discovering new things all the time.

My niece who's about 35 I think with Juvenile Diabetes, just had 2 transplants. She's doing very well. I remember when she got her insulin pump. That was when they first came out.
What blessing it was for her!

J.D.R.F. is a very worthy foundation to support.

wallycrawler said...

Handmaiden it is very encouraging that medical science is moving forward, but with those two assholes in charge of our the government subsidies, we're way behind. I'd say eight years behind in stem cell research. Why? Because George and Co. believe it's against "GOD" to practice this science!!! At lest that's what they say outwardly. In reality they're against it because so are Drug Companies! If stem cell science keeps going the Pharmaceuticals Companies will lose huge profits!!! Stephen Harper (our Prime Minister) and George Bush are backed with huge special interest monies from these lobbyists. Second only to the Big Oil Lobbyists.
The science of stem cell research is coming from overseas Europe , India, China, South America, Africa... The Funny Thing Is Most Of These Scientists are from North America! Our own research scientists can't work for our governments!!! That'll put Canada and da U.S. behind the eight ball in the first few years of a cure. And it will cost us more money for most treatments!

When Doctor Banting invented insulin treatments he Willed the cost of insulin as a non-money making drug. The Pharmaceutical companies have all but slip-shoted that whole idea and have raised prices all across the U.S. If we had the right people in charge of our Governments that would never have happened. Get ready for more of the same if research goes by simple drug treatments.

concerned citizen said...

When Doctor Banting invented insulin treatments he Willed the cost of insulin as a non-money making drug.
I didn't know that. Those greedy basturds!

All we can do is our little part, though to raise awareness on issues that concern us. keep plugging along. It makes a difference. My little endeavor is blowing wide open. Unfortunatly, it took a horrible tragedy to finally open some eyes. Go take a look.

Keshi said...

thats really great news!

I hv a cousin with the same thing. I must tell him abt this.


TK Kerouac said...

Its amazing what they can do now a days. I saw an article in the star last week but I'm afraid I only glanced over it
It was about how teenage girls are skipping their insulin and its a real problem with the girls, not the boys,
Why would that be?
should have read the article

wallycrawler said...

You should really do that Keshi.

And Thank You


T.K. the girls skip their insulin because it keeps them thin. Without insulin their bodies will become emaciated. Within a year or two the diabetic body starves itself to death. They will probably succumb of heart or kidney failure before their bodies would actually die from starvation though.
That's not a good thing to do anyhoo.

Even if they catch it in time these girls will go blind in their twenties or thirties. It's hard to ever fix poor practices when your a Type 1 diabetic! It's very unforgiving. Hopefully they stop this kinda practices.

Keshi said...

yep...cos he injects Insulin twice every single day. I feel bad for him cos he's young...and he has to do that even when he's at a party etc. It must be a tough life!


wallycrawler said...

Keshi you should bring up the pump to your cousin. The freedom of have the pump is immeasurable. It also keeps your blood sugars well balanced. Steph's pump is a little bit of a strange thing to have hooked up ta ya, but most people think it's a cell phone or a IPod.
It was the best thing for her and all her buds that have diabetes.